1a. The medical way to fight Covid19 using Chloroquine. June 2020
What about Chloroquine?
1. What can be done to stop the Coronavirus? One big possibility is the use of Chloroquine as a preventative. (It's a once a week pill you take if you visit an area where there is malaria.) Millions of people mainly in Southern India, africa and parts of south east asia now take Chloroquine as both a preventative and as a cure for malaria. They have been taking it for 75 years so it's got a long safety record (though it has a number of side effects).
Chloroquine has been shown to be active against the Coronavirus in vitro and hospitals in China are starting to administer Chloroquine to Coronavirus patients (one 500mg tablet twice a day for ten days). Which is about the same as the dosage for treating active Malaria infections. This article about a study in Oklahoma is very comprehensive and should definitely be read (after you finish this page).
The important question is this: does the prophylactic use of Chloroquine (for malaria) at the prescribed dose of one 500mg tablet a week (after loading with 1500mg) also confer protection from the Coronavirus? This question can be answered simply and quickly by asking people who take Chloroquine for Malaria, lupus and arthritis if they have caught the Coronavirus (especially if they are living with someone who has the virus). Alternately questioning people who have contracted the Corona virus as to whether or not they take Chloroquine for malaria prevention might be much easier. In fact nearly every person who has contracted that virus has provided a medical history including what drugs they are taking. It should be easy to find out if they have been taking chloroquine or hydroxychloroquine to prevent malaria.
Anyway this survey/study doesn't take millions of dollars and months to find out if Chloroquine confers prophylactic preventative protection to the Coronavirus. This survey can be done with a telephone and a group of telemarketers. A team of Mumbai marketers come to mind. There are probably 100,000 phone opereators in India who are able to call people and are looking for work. Southern India sounds like a great location as they have lots of Malaria and I am sure there are a fair number of Coronavirus cases. Some "Hollywood type" could easily run the whole project and thereby help billions of people. We could have the answer as to whether or not Chloroquine prevents Corona virus infections and do the whole thing in three weeks or less.
Actually this data may already exist There must be some ethical data analytics companies that are plugged in better than and more ethically than Surgisphere is. I'll try to find them. Want to help? We may not have to start from scratch.
If nobody who is taking Chloroquine has caught the Coronavirus then we have a simple way to keep from getting it.
About Chloroquine: One problem with chloroquine is that it's got a half life of 90 days. It's sort of like a time released version of quinine (half life 11 hrs, vs 22 days for hydroxychloryquen and 90 days for chloroquine). Take one tablet and 90 days later half of it is still in your system. You can see why taking 20 tablets in a ten day period poisons people. How can it not? Dugh!
1b. That brings us to the possible use of quinine. I think it is likely to be pretty much the same as Chloroquine and hydroxychloroquine. What's the truth about these two drugs and acute infections of Covid-19?
Is this the healthier solution to the Corona Virus?
2.It is called Inosine. It's a precursor of two of the four components of RNA and DNA: Guanine and adenine (including Adenosine Tri Phosphate, ATP, which fuels the body at the cellular level). Inosine occurs naturally in our food but not in substantial amounts. It is often used as a supplement in athletics and as a legal doping agent in horse racing. One real truth for women is that it improves their complexions....from the inside out. Often blemishes and even lines disappear. More on that later.
Most importantly it appears that loading the system with inosine increases antibody production.
One way inosine seems to win out is simply a matter of competition. When DNA is incorporating guanine or adenine into the RNA that it is producing it is a scavenging process so it occasionally grabs and incorporates a virus strand by mistake. That is essentially how virus infections occur. They are incorporated into the RNA largely by accident. By adding inosine to your diet the amount of adenine and guanine increases and simply outnumbers the virus and leaves it 'in the dust' to be destroyed by the immune system.
This tilts the body in favor of making more healthy RNA than infected RNA. It makes all the difference in the world. Inosine also does a stupendous job of stimulating the immune systems production of antibodies. RNA synthesis seems to be at least partially limited by and controlled by the amount of available inosine.
It usually takes a couple of days to take effect. It takes that long for the antibodies to really start getting produced by the body.
Don't confuse Inosine with the 'drug' Isoprinosine (aka Inosine Pranobex, Methisoprinol, etc) and don't confuse the later of actually being a drug. It's not a drug. They are really the same thing.
My research in the 1960's and early 70's into the original studies comparing inosine and Isoprinosine is interesting. (In high school I had no social life so I spent entire weekends in the UCLA BioMed Library. I also studied biochemistry and consequentially epidemiology including small pox of which there were still outbreaks.) Isoprinosine is simply inosine mixed with a salt of acedoben (acetylated PABA aka Vitamin B10) and dimethylaminoisopropanol. Isoprinosine's effects seem to be identical to inosine. It is just slightly better absorbed, as I recall. That is hardly a reason to get a patent on it and then make millions marketing this natural food as a drug. However, by patenting Isoprinosine it had the very desirous effect of getting it taken seriously by the medical establishment! As such it has been tested and there are lots of studies which have been made using it! Google it and you will see. Like this study of it's effect on the flu virus.
You can probably safely extrapolate the results obtained by Isoprinosine studies to the effects that can be obtained with inosine..and at less than 1/10 the cost. Try starting with 2 grams of inosine a day in at least two divided doses. (Inosine has an 11 hour half life.) If you get a good response after about five days you can probably get by fine on 1/2 to 1 gram a day, divided.
You will also get a huge increase in ATP production. The increase in ATP production is why inosine is used as a legal doping agent in horse racing. Five grams given each day for three days preceding the race(s). Apparently it takes 3-4 days for inosine to really crank up the production of ATP and RNA in horses.
Someone should do a study. If I can be of any help then please let me know. In addition to inosine you may consider including another nutrient, Uridine which also occurs in our food but not in substantial amounts. It is one of the five nucleosides that make up Nucleic acids. It appears to supply the other two components of RNA, uracil and cytosine. That way there can be no lack of the building blocks of RNA. The addition of uridine to inosine seems to shut down viruses very quickly. It works best if the inosine is taken twice daily and the Uridine is taken at the same time but at least once a day. Uridine has a biphasic half life which causes it to accumulate. It is rather complex but Uridine seems to form a pool of metabolites from which thymine and cytosine are formed but I am now getting into conjecture so never mind. Don't use uridine if you have uric acid problems.
I owned a nutritional company in the 1980's from which I sold this combination of inosine and uridine under the trade name of Ribodan. It worked but there wasn't the insane need for combating viruses as there exists today. I sold it mainly to women who wanted to improve their complexion....from the inside out. 75-90% of the women who used it for their complexion said that it dramatically improved it with even lines going away. Over 50% of customers in general stated that it improved their complexion.
Who knew the Corona virus would come along and create another need for such a highly turned on immune system? I sure didn't.
The Corona virus is a monster the likes of which has not been seen since smallpox ravaged the earth. It targets those over 50 years of age and those with compromised immune systems. Children usually fight it off without to much problem. In fact it looks all the world like a cold or a mild case of the flu most of the time with children. And that is what makes it so sinister. The most innocent of our society spread it the most efficiently. It lasts a long time (that is more than a week). Like a cold that they can't seem to shake off. However he or she may have innocently passed it to a dozen schoolmates and playmates who then pass it along to their family members. They come down with it one day and a week later half their classmates have it and by the time another week has gone by half their parents will have it. That is when it gets dangerous. The older and more infirm a person is the more likely they are to die.
Both Inosine and Uridine can usually be purchased on Amazon.
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